Regulation of cyclic nucleotides in the urinary tract

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چکیده

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Regulation of cyclic nucleotides in the urinary tract.

Cyclic nucleotide levels are controlled through their synthesis from nucleotide triphosphates by cyclases and their degradation to 5'-monophosphates by phosphodiesterases (PDEs). Components controlling cyclic AMP-induced relaxation in the urinary tract include receptors, inhibitory and stimulatory G-proteins, isoforms of adenylyl cyclase and PDEs. The responsiveness of PDEs to a variety of phys...

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Radioimmunoassay for Cyclic Nucleotides

Sensitive and specific radioimmunoassays have been developed for cyclic adenosine 3’, 5’-monophosphate (CAMP), cyclic guanosine 3’ ,5’-monophosphate (cGMP), cyclic inosine 3’ ,5’-monophosphate (cIMP), and cyclic uridine 3’, 5’monophosphate (cUMP). These assays are based upon competition of the cyclic nucleotide with isotopically labeled cyclic nucleotide derivatives for binding sites on specifi...

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ژورنال

عنوان ژورنال: Journal of Smooth Muscle Research

سال: 2005

ISSN: 0916-8737,1884-8796

DOI: 10.1540/jsmr.41.1